Endocrine Abstracts

The circulating levels of serum TSH and thyroid hormones represent biochemical phenotypes reflecting thyroid homeostasis. Studying the regulation of biochemical measures related to the thyroid in healthy individuals could prove essential in understanding the pathways that eventually lead to thyroid disease. It is the combined effect of genetic and environmental factors that give rise to these endophenotypes. It has been established that the measures reflecting thyroid homeosta...

The effect of age on thyroid function and hypothalamic–pituitary–thyroid axis have been studied. The objective of the study was to examine: correlation between triiodothyronine (T3) and thyroxine (T4) hormone levels, thyroid antibodies and thyroglobulin levels and old age; capability of TSH and prolactin (PRL) response to TRH, in TRH test depending on age and gender of the examines. We have tested 125 subjects, classified in 4 group. First, cont...

Thyroid abscess is a rare condition because of the thyroid gland anatomical and biochemical nature. We report a rare case of a rapidly developed thyroid abscess in the background of follicular thyroid nodule.A 77 years old lady admitted for elective right thyroidectomy. She had a history of goiter with normal TFTs. FNA cytology revealed Thy3, Hurthle cell neoplasia. The pre-operation CT scan showed right thyroid large nodule with heterogonous enhancement...

Introduction: Clinical trials have show n that improved glycemic control reduces the incidence and progression of diabetes complications. One of the most important steps in diabetes treatment is to educate patients how to manage self monitorining blood glucose (SBGM) and adjust their life habits with their diabetes. A new diabetes management concept of structured testing is supported by Accu -Chek 360 View.Objectives: Assess the impact of structured test...

Background: Incidence of hypercalcaemia during pregnancy is difficult to estimate as routine calcium screening is not recommended. Literature is conflicting if hypercalcemia results in worse maternal and fetal outcomes.Objectives: Aim of this study is to determine frequency and association of hypercalcaemia in pregnancy with early maternal and fetal outcomes.Methods: This retrospective cohort study included gestations with expected...

Several preparations of thyroxine are available nowadays but is a great challenge for every clinician when the oral and intramuscular administration is failing and has to consider long term intravenous administration. This is a 42 years old lady who had a total thyroidectomy for Graves thyrotoxicosis. She commenced on multiple oral preparations of thyroxine and liothyroxine with no biochemical response. This is not a case of pseudomalabsorption as oral absorption studies of hi...

An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) has been suggested in previous studies. Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors, the aim of this study was to assess whether non-obese PCOS women with the variant allele G have different response on hirsutism and on hormonal and metabolic variables to oral contracepti...

Introduction: Primary malignant thyroid teratoma is a rare neoplasm. Even rarer is the concomitance of the mentioned tumor and papillary thyroid cancer.Case report: We report a case of a 44-year old woman diagnosed with Hasimoto thyroiditis and multinodular, non-toxic goiter since 2004. The two larger, initially non palpable nodules were located in right thyroid lobe, 16 and 12 mm in diameter respectively. Under suppressive thyroxine therapy the diameter...

Objective: To determine the predictive risk factors for the development of type 2 diabetes mellitus (DM) in patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) during the 8.5 follow up.Research design and methods: This is an 8-year prospective study in a randomly selected urban population including 2838 subjects aged ≥40 years living in Krakow. Seven hundred and six had IGT (387) or IFG (319) based on WHO criteria and 2...

Background:Circulating levels of IGFBP-3 are inversely associated with the risk of developing colorectal cancers (CRC). In addition to modulating IGF bioavailability, IGFBP-3 also exerts independent pro-apoptotic effects. Furthermore, the mode of action of several apoptotic and antiproliferative agents, including vitamin D, has been shown to involve induction of IGFBP-3.Aims:To quantitate and compare IGFBP-3 ...